Best NFL underdog picks and predictions for Week 12

13 days ago Sportsbook Wire

Thanksgiving Day means an accelerated start to Week 12, so before you sit down for some turkey and good fixings, it’s time to look at some underdog picks for the week.

Week 11 wasn’t a good week for the underdog. Only 3 underdogs — the Tennessee Titans, Detroit Lions and Las Vegas Raiders — won outright, although 6 underdogs covered the spread in their losses, including the Indianapolis Colts and Carolina Panthers.

Below, we analyze Tipico Sportsbook’s NFL odds and lines, and tab the best NFL Week 12 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

All 3 of our best underdog picks from Week 11 hit — the Bears and Chargers covered the spread and the Raiders won outright — bringing the year to date record to 16-17.

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NFL underdog predictions: Week 12

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 8:25 a.m. ET. All games Sunday and ET unless noted.

Buffalo Bills at DETROIT LIONS +9.5 (-110) – Thursday 12:30 p.m. ET (CBS)

The Lions have won 3 straight games and, of their 6 losses this season, they have lost by double digits only twice. Detroit has scored at least 30 points in 5 of its games and has a 6th with 27 points, they it has the offense to keep up.

The Bills have 4 double-digit wins this season but 2 came in the first 2 weeks.

Buffalo is 5-4-1 ATS and Detroit is 6-4 ATS.

Check out: All Week 12 odds and lines

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

HOUSTON TEXANS +13 (-108) at Miami Dolphins – 1 p.m. (CBS)

The Texans have lost by more than 13 points only once this season and the Dolphins have only won by more than 13 points once.

The Texans are 1-8-1 overall this season but are 4-5-1 ATS. Meanwhile, the Dolphins are 5-5 ATS.

Play our free daily Pick’em Challenge and win! Play now!

Los Angeles Chargers at ARIZONA CARDINALS (+145) – 4:05 (CBS)

The Cardinals are expected to get QB Kyler Murray and WR Marquise Brown back this week. The Arizona offense works best when it can run the ball, which it does much better when Murray plays. The Chargers are awful against the run, ranking 30th in rushing yards allowed per game (148.4) and dead last in yards per carry allowed (5.5).

The Cardinals are 4-0 when opponents rush for fewer than 100 yards and 0-6 when they rush for 100 or more. The Chargers have only passed 100 rushing yards as a team twice this season.

Want action on any of these NFL underdogs or other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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